BBS

Scientific publications

Original papers

Raji A, Opfer R, Ostwaldt AC, Suppa P, Spies, L, Winkler G (2018) MRI-based brain volumetry at a single time point complements clinical evaluation of patients with multiple sclerosis in an outpatient setting Frontiers in Neurology doi: 10.3389/fneur.2018.00545.

Buchert R, Lange C, Suppa P, Apostolova I, Spies L, Teipel S, Dubois B, Hampel H, Grothe MJ (2018) Magnetic resonance imaging-based hippocampus volume for prediction of dementia in mild cognitive impairment: Why does the measurement method matter so little? Alzheimers Dement. DOI: 10.1016/j.jalz.2018.03.006.
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Opfer R, Ostwaldt AC, Sormani MP, Gocke C, Walker-Egger C, Panogaran M, De Stefano N, Schippling S (2018) Estimates of age-dependent cut-offs for pathological brain volume loss using SIENA/FSL – A longitudinal brain volumetry study in healthy adults. Neurobiol Aging. 65:1-6.
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Opfer R, Ostwaldt AC, Walker-Egger C, Panogaran M, Sormani MP, De Stefano N, Schippling S (2018) Within patient fluctuation of brain volume estimates from shortterm repeated MRI measurements using SIENA/FSL. J Neurol. 265:1158-1165.
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Apostolova I, Lange C, Mäurer A, Suppa P, Spies L, Grothe MJ, Nierhaus T, Fiebach JB, Steinhagen-Thiessen E, Buchert R (2018) Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation. Neurobiol Aging. 65:41-50.
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Apostolova I, Lange C, Suppa P, Spies L, Klutmann S, Adam G, Grothe MJ, Buchert R (2017) Impact of plasma glucose level on the pattern of brain FDG uptake and the predictive power of FDG PET in mild cognitive impairment. Eur J Nucl Med Mol Imaging. 45:1417-1422.
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Lange C, Suppa P, Pietrzyk U, Makowski MR, Spies L, Peters O, Buchert R (2017) Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status. J Alzheimers Dis. 61:373-388.
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Levy Nogueira M, Samri D, Epelbaum S, Lista S, Suppa P, Spies L, Hampel H, Dubois B, Teichmann M (2017) Alzheimer's Disease Diagnosis Relies on a Twofold Clinical-Biological Algorithm: Three Memory Clinic Case Reports. J Alzheimers Dis. 60:577-583.
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Cavedo E, Suppa P, Lange C, Opfer R, Lista L, Galluzzi S, Schwarz AJ, Spies L, Buchert R, Hampel H (2017) Fully automatic MRI-based hippocampus volumetry using FSL-FIRST: intra-scanner test-retest stability, inter-field strength variability, and performance as enrichment biomarker for clinical trials using prodromal target populations at risk for Alzheimer's disease. J Alzheimers Dis. 60:151-164.
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Schippling S, Ostwaldt AC, Suppa P, Spies L, Manogaran P, Gocke C, Huppertz HJ und Opfer R (2017) Global and regional annual brain volume loss rates in physiological aging. J Neurol. 264:520-528.
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Egger C, Opfer R, Wang C, Kepp T, Sormani MP, Spies L, Barnett M, and Schippling S (2017) MRI FLAIR lesion segmentation in Multiple Sclerosis: Does automated segmentation hold up with manual annotation? NeuroImage: Clinical. 13:264–270.
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Lange C, Suppa P, Mäurer A, Ritter K, Pietrzyk U, Steinhagen-Thiessen E, Fiebach JB, Spies L, and Buchert R (2016) Mental speed is associated with the shape irregularity of white matter MRI hyperintensity load. Brain Imaging and Behavior. 11:1720-1730.
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Ritter K, Lange C, Weygandt M, Mäurer A, Roberts A, Estrella M, Suppa P, Spies L, Prasad V, Steffen I, Apostolova I, Bittner D, Gövercin M, Brenner W, Mende C, Peters O, Seybold J, Fiebach JB, Steinhagen-Thiessen E, Hampel H, Haynes JD, and Buchert R (2016) Combination of structural MRI and FDG-PET of the brain improves diagnostic accuracy in newly manifested cognitive impairment in geriatric inpatients. J Alzheimers Dis. 54:1319–1331.
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Suppa P, Hampel H, Kepp T, Lange C, Spies L, Fiebach JB, Dubois B, Buchert R (2016) Performance of hippocampus volumetry with FSL-FIRST for prediction of Alzheimer's disease dementia in at risk subjects with amnestic mild cognitive impairment. J Alzheimers Dis. 51:867-873.
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Opfer R, Suppa P, Kepp T, Spies L, Schippling S und Huppertz HJ (2016) Atlas based brain volumetry: how to distinguish regional volume changes due to biological or physiological effects from inherent noise of the methodology. Magn Reson Imaging. 34:45-461.
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Lange C, Suppa P, Frings L, Brenner W, Spies L und Buchert R (2016) Optimization of Statistical Single Subject analysis of Brain FDG PET for the Prognosis of Mild Cognitive Impairment-to-Alzheimer’s Disease Conversion. J Alzheimers Dis. 49:945-959.
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Burkhardt T, Lüdecke D, Spies L, Wittmann W, Westphal M und Flitsch J (2015) Hippocampal and cerebellar atrophy in patients with Cushing’s disease. Neurosurg Focus. 39:E5
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Suppa P, Hampel H, Spies L, Fiebach J, Dubois B und Buchert R (2015) Fully automated atlas-based hippocampal volumetry for clinical routine: validation in subjects with mild cognitive impairment from the ADNI cohort. J Alzheimers Dis. 46:199–209.
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Suppa P, Anker U, Spies L, Bopp I, Rüegger-Frey B, Klaghofer R, Gocke C, Hampel H, Beck S und Buchert R (2015) Fully automated atlas-based hippocampal volumetry for detection of Alzheimer’s disease in a memory clinic setting. J Alzheimers Dis. 44:183–193.
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Boelmans K, Spies L, Sedlacik J, Fiehler J, Jahn H, Gerloff C, Münchau A. (2014) A novel computerized algorithm to detect microstructural brainstem pathology in Parkinson's disease using standard 3 Tesla MR imaging. J Neurol. 261:1968-75
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Spies L, Tewes A, Suppa P, Buchert R, Winkler G und Raji A. (2013) Fully automatic detection of deep white matter T1 hypointense lesions in multiple sclerosis. Phys Med Biol. 58:8323–37.
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Arlt S, Buchert R, Spies L, Eichenlaub M, Lehmbeck J und Jahn H. (2013) Association between fully automated MRI based volumetry of different brain regions and neuropsychological test performance in patients with mild cognitive impairment and early dementia. Eur Arch Psychiatry Clin Neurosci. 263:335-44.
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Selected conference contributions

Peters O, Suppa P, Haas B, Buchert R, Spies L, Heuser I (2016) Robustness of MRI-based volumetry for the prediction of short-term conversion from mild cognitive impairment to Alzheimer´s dementia. CTAD, San Diego, USA
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Opfer R, Suppa P, Spies L, Egger C, Schippling S (2016) Consistency of longitudinal brain volume loss assessment in MS using SIENA/FSL. ECTRIMS, London, UK
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Opfer R, Kepp T, Suppa P, Spies L, Egger C, Schippling S (2015) Assessing intra- and interscanner variability of automated brain volumetry using SPM12, SIENA, SIENAX. ECTRIMS, Barcelona, Spain
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